Search results
Results from the WOW.Com Content Network
"Pulmonary hyalinizing granuloma" is a lesion characterized by keloid-like fibrosis in the lung and is not granulomatous. Similarly, radiologists often use the term granuloma when they see a calcified nodule on X-ray or CT scan of the chest. They make this assumption since granulomas usually contain calcium, although the cells that form a ...
These granulomas are the main reason for the name granulomatosis with polyangiitis, although it is not an essential feature. Nevertheless, necrotizing granulomas are a hallmark of this disease. However, many biopsies can be nonspecific and 50% provide too little information for the diagnosis of GPA.
Focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, necrotizing glomerulonephritis: Granulomatosis with polyangiitis: Hakim Triad [1] (Adams Triad) Urinary incontinence, Gait disturbance, Dementia: Normal pressure hydrocephalus: Triad (Triad of Sandblom) Malena, Obstructive jaundice, Biliary colic: Hemobilia ...
Standard bronchoscopy usually shows chronic inflammation of lung tissue, and granulomas with poorly-defined margins. [1] Lung biopsy usually reveals non-necrotizing granulomatous inflammation. [7] It also shows "foamy" macrophages and crystals of oxalic acid. [3] Hyperplasia tends to occur in type 1 pneumocytes and not in type 2 pneumocytes. [3]
Differential diagnosis [ edit ] The signs and symptoms of microscopic polyangiitis may resemble those of granulomatosis with polyangiitis (GPA) (another form of small-vessel vasculitis) but typically lacks the significant upper respiratory tract involvement (e.g., sinusitis ) frequently seen in people affected by GPA.
Granuloma formation is seen in other diseases such as tuberculosis and sarcoidosis. Sarcoidosis, like berylliosis, also produces granulomas without a necrotic core, and so distinction between the two processes can be difficult. Ultimately, this process leads to restrictive lung disease (a decrease in diffusion capacity).
Caseous necrosis in the kidney. In caseous necrosis no histological architecture is preserved (unlike with coagulative necrosis). [5] [6] On microscopic examination with H&E staining, the area is acellular, characterised by amorphous, roughly granular eosinophilic debris of now dead cells, [6] also containing interspearsed haematoxyphilic remnants of cell nucleus contents. [5]
Sarcoidosis is characterized by the formation of non-necrotizing ("non-caseating") granulomas in various organs and tissues. [95] Giant cells , specifically Langhans giant cells , are often seen in sarcoidosis. [ 96 ]