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A depiction of the ovarian cycle in animals. In human adult females, the primordial follicle is composed of a single oocyte surrounded by a layer of closely associated granulosa cells. In early stages of the ovarian cycle, the developing follicle acquires a layer of connective tissue and associated blood vessels. This covering is called the theca.
The innermost layer is the ovarian medulla. [8] It can be hard to distinguish between the cortex and medulla, but follicles are usually not found in the medulla. Follicular cells are flat epithelial cells that originate from surface epithelium covering the ovary.
The growth of the dominant follicle during the follicular phase is about 1.5 mm per day (±0.1 mm), both in natural cycles and for any dominant follicle developing while taking combined oral contraceptive pill. [8] Performing controlled ovarian hyperstimulation leads to a greater recruitment of follicles, growing at about 1.6 mm per day. [8]
The ovarian cycle is divided into several phases: Follicologenesis: Synchronously with ootidogenesis, the ovarian follicle surrounding the ootid has developed from a primordial follicle to a preovulatory one. The primary follicle takes four months to become a preantral, two months to become antral, and then passes to a mature (Graaf) follicle.
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The follicular phase, also known as the preovulatory phase or proliferative phase, [1] is the phase of the estrous cycle (or, in primates [2] for example, the menstrual cycle) during which follicles in the ovary mature from primary follicle to a fully mature graafian follicle.
Ovarian stroma differs from typical connective tissue in that it contains a high number of cells. The stroma cells are distributed in such a way that the tissue appears to be whorled. Stromal cells associated with maturing follicles may acquire endocrine function and secrete estrogens. The entire ovarian stroma is highly vascular. [1]
Tubal branches of ovarian artery Vessels of the uterus and its appendages, rear view. The arteries of the internal organs of generation of the female, seen from behind.
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