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Escherichia virus T4 is a species of bacteriophages that infect Escherichia coli bacteria. It is a double-stranded DNA virus in the subfamily Tevenvirinae of the family Straboviridae . T4 is capable of undergoing only a lytic life cycle and not the lysogenic life cycle .
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The enterobacteria phage T4, a highly studied phage, targets E. coli for infection. [citation needed] While phage therapy as a treatment for E. coli is unavailable in the US, some commercially available dietary supplements contain strains of phage that target E. coli and have been shown to reduce E. coli load in healthy subjects. [58]
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The first safety trial in healthy human volunteers for a phage was conducted by Bruttin and Brüssow in 2005. [117] They investigated the oral administration of Escherichia coli phage T4 and found no adverse effects of the treatment. [medical citation needed] Historical record shows that phages are safe, with mild side effects, if any. [118]
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Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.