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Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. [1] The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved.
drug sensitization or reverse tolerance – the escalating effect of a drug resulting from repeated administration at a given dose; drug withdrawal – symptoms that occur upon cessation of repeated drug use; physical dependence – dependence that involves persistent physical–somatic withdrawal symptoms (e.g., fatigue and delirium tremens)
A person cannot become resistant to antibiotics. Resistance is a property of the microbe, not a person or other organism infected by a microbe. [14] All types of microbes can develop drug resistance. Thus, there are antibiotic, antifungal, antiviral and antiparasitic resistance. [4] [8] Antibiotic resistance is a subset of antimicrobial resistance.
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Cross-resistance is the idea is that the development of resistance to one substance subsequently leads to resistance to one or more substances that can be resisted in a similar manner. It occurs when resistance is provided against multiple compounds through one single mechanism, like an efflux pump. [3]
Resistance to a drug. A resistance mutation is a mutation in a virus gene that allows the virus to become resistant to treatment with a particular antiviral drug.The term was first used in the management of HIV, the first virus in which genome sequencing was routinely used to look for drug resistance.
Development of resistance is associated with poor management of cases. As of 2011, drug susceptibility testing is done in less than 5% of TB cases globally [3] Without testing to determine drug resistance profiles, MDR- or XDR-TB patients may develop resistance to additional drugs and can continue to spread the disease to others. TDR-TB is ...
Researchers have found that the far more common overdose risk with Suboxone occurs when an addict shoots up the drug intravenously in combination with a respiratory depressant, such as a benzodiazepine like Xanax. The Times article did not question the efficacy of Suboxone when used properly.