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The IgG responses to bacterial capsular polysaccharide antigens are mediated primarily via IgG2 subclass, and deficiencies in this subclass result in susceptibility to certain bacterial species. [8] IgG2 represents the major antibody subclass reacting to glycan antigens but IgG1 and IgG3 subclasses have also been observed in such responses ...
Immunoglobulin G (IgG) is a type of antibody. Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation . [ 1 ] IgG molecules are created and released by plasma B cells .
Humans exhibit abundance of genotypes and phenotypes, however all currently licensed IgG therapeutic immunoglobulins are developed as single allotypic/ polymorphic form. Patients that are homozygous for alternative phenotype are therefore at higher risk of developing potential immune response to the therapy.
The arrangement or processes that put together different parts of this antibody molecule play important role in antibody diversity and production of different subclasses or classes of antibodies. The organization and processes take place during the development and differentiation of B cells. That is, the controlled gene expression during ...
All patients with IgG deficiency require extensive diagnostic evaluation before the patient is diagnosed with a clinically significant IgG subclass deficiency. Depending on a clinical presentation, complete blood count , test for total serum immunoglobulins (IgG, IgA, IgM and subclass levels of IgG) and other tests are performed.
n/a Ensembl ENSG00000211892 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.62 – 105.63 Mb n/a PubMed search n/a Wikidata View/Edit Human Ig gamma-4 chain C region is a protein that in humans is encoded by the IGHG4 gene. See also Immunoglobulin heavy chain (IGH) Immunoglobulin G (IgG) Subclasses of IgG, IgG4 is encoded by this gene IgG4-related ...
Antibody-mediated opsonisation (marking) of pathogens depends on high affinity paratope-epitope interactions. Immunoglobulins are highly effective opsonins, with the IgG subclasses IgG1 and IgG3 being recognised as the most efficacious opsonins in humans. [1] Antibodies structurally contain two important domains
Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]