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Lysogeny, or the lysogenic cycle, is one of two cycles of viral reproduction (the lytic cycle being the other). Lysogeny is characterized by integration of the bacteriophage nucleic acid into the host bacterium's genome or formation of a circular replicon in the bacterial cytoplasm .
The viruses then switch from lysis to lysogeny, so as to not deplete all available hosts. [ 1 ] According to a team led by Alberto Marina at the Biomedical Institute of Valencia in Spain, also studying the Bacillus subtilis/ SPbeta phage system, arbitrium (AimP) binds to the AimX transcription factor AimR, and suppresses the activity of AimX, a ...
The lysis-lysogeny decision is mainly influenced by the competition between Cro and CII, resulting in the determination of whether or not sufficient CI repressor is made. If so, CI represses the early promoters and the infection is shunted into the lysogenic pathway.
Computer modeling and simulation suggest that random processes during infection drive the selection of lysis or lysogeny within individual cells. [26] However, recent experiments suggest that physical differences among cells, that exist prior to infection, predetermine whether a cell will lyse or become a lysogen.
A lysogen or lysogenic bacteria is a bacterial cell that can produce and transfer the ability to produce a phage. [1] A prophage is either integrated into the host bacteria's chromosome or more rarely exists as a stable plasmid within the host cell.
Transduction happens through either the lytic cycle or the lysogenic cycle. When bacteriophages (viruses that infect bacteria) that are lytic infect bacterial cells, they harness the replicational, transcriptional, and translation machinery of the host bacterial cell to make new viral particles ().
Helix-turn-helix DNA binding domains (pink) in tetramerized cII protein [1] [7]. cII binds DNA as a tetramer, composed of identical 11 kDa subunits. [7] Although the cII gene encodes 97 codons, the mature cII protein subunit only contains 95 amino acids due to post-translational cleavage of the first two amino acids (fMet and Val).
P1 is a temperate bacteriophage that infects Escherichia coli and some other bacteria. When undergoing a lysogenic cycle the phage genome exists as a plasmid in the bacterium [1] unlike other phages (e.g. the lambda phage) that integrate into the host DNA.