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CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. [5] [6] [7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins. [8] CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell ...
The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.
The cell cycle is the cycle of events in a cell from one cell division to the next. Subcategories. This category has the following 5 subcategories, out of 5 total. ...
M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene. [5] This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family.
The protein encoded by this gene is a key licensing factor in the assembly of pre-replication complexes (pre-RC), which occurs during the G1 phase of the cell cycle. In the assembly of pre-RCs, origin recognition complexes (ORC1-6) recognize and bind to DNA replication origins.
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene [5] [6] in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase .
In eukaryotes, the cell cycle consists of four main stages: G 1, during which a cell is metabolically active and continuously grows; S phase, during which DNA replication takes place; G 2, during which cell growth continues and the cell synthesizes various proteins in preparation for division; and the M phase, during which the duplicated ...
A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. [8] [9] [10] Loss of p27 expression has been observed in metastatic canine mammary carcinomas. [11] [12] [13] Decreased TGF-beta signalling has been suggested to cause loss of p27 expression in this tumor type. [14]