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Mirabegron, sold under the brand name Myrbetriq among others, is a medication used to treat overactive bladder. [5] Its benefits are similar to antimuscarinic medication such as solifenacin or tolterodine . [ 6 ]
In 2001 Mirabegron began clinical development in phase 1 clinical study. The indications were type 2 diabetes, lower urinary tract symptoms, OAB and bladder outlet obstruction. [21] From 2004 to 2008 phase 2 clinical trials were performed. However the development of Mirabegron for type two diabetes was interrupted. [21]
Indications of administration for β agonists include: Bradycardia (slow heart rate) Asthma; Chronic obstructive pulmonary disease (COPD) Heart failure; Allergic reactions; Hyperkalemia; Beta blocker poisoning; Premature labor (this is an off-label use and could be detrimental) [7]
Here vibegron differs from the previous overactive bladder drug mirabegron, which was known to be associated in various drug–drug interactions by inhibiting CYP2D6 or inducing CYP3A4, CYP2D6 and CYP2C9 in the liver. [13] [4] [14] [15] [16] [17]
Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action.
Solabegron (code name GW-427,353) is a drug which acts as a selective agonist for the β 3 adrenergic receptor.It is being developed for the treatment of overactive bladder and irritable bowel syndrome.
This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.
Acebutolol is a cardioselective beta-1 blocker which also considered a partial agonist due to its intrinsic sympathomimetic activity (ISA). This means it provides low-grade beta stimulation at rest but acting as typical beta-blockers when sympathetic activity is high. [3]
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