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The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting tubule. ... the distal convoluted tubule cells, ...
Thus, loss of NCC function reduces sodium and chloride reabsorption in the distal convoluted tubule. This can lead to a lower blood pressure in these patients. [12] Loss of NCC function has several other effects. Loss of SLC12A3 has been shown to lead to a shorter distal convoluted tubule, at least in mice. [13]
Urinary casts are microscopic cylindrical structures produced by the kidney and present in the urine in certain disease states. They form in the distal convoluted tubule and collecting ducts of nephrons , then dislodge and pass into the urine, where they can be detected by microscopy .
This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
The sodium-chloride symporter (also known as Na +-Cl − cotransporter, NCC or NCCT, or as the thiazide-sensitive Na +-Cl − cotransporter or TSC) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron.
The distal convoluted tubule has a different structure and function to that of the proximal convoluted tubule. Cells lining the tubule have numerous mitochondria to produce enough energy for active transport to take place. Much of the ion transport taking place in the distal convoluted tubule is regulated by the endocrine system.
Proximal convoluted tubule. Normal individuals have two copies of the MUC1 and UMOD genes. The genes produce the protein mucin-1 and uromodulin, respectively. These proteins are expressed only in certain cells in the kidney – the thick ascending limb of Henle and distal convoluted tubule – both parts of the kidney tubule. The protein coats ...
Early distal convoluted tubule: ... Nephrology is the subspeciality under Internal Medicine that deals with kidney function and disease states related to renal ...
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