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Protamine insulin was first created in 1936 and NPH insulin in 1946. [1] It is on the World Health Organization's List of Essential Medicines. [4] NPH is an abbreviation for "neutral protamine Hagedorn". [1] In 2020, insulin isophane was the 221st most commonly prescribed medication in the United States, with more than 2 million prescriptions.
Sample regimen using insulin NPH and regular insulin before breakfast before lunch before dinner at bedtime NPH dose 12 units 6 units regular insulin dose if fingerstick glucose is (mg/dL) [mmol/L]: 70–100 [3.9–5.5] 4 units 4 units 101–150 [5.6–8.3] 5 units 5 units 151–200 [8.4–11.1] 6 units 6 units
- Rapid acting (i.e. insulin lispro) with onset in 15 minutes and duration of about 4 hrs. - Short acting (i.e. regular insulin) with onset in 30 minutes and duration of about 6 hrs. - Intermediate acting (i.e NPH insulin) with onset in 2 hours and duration of about 14 hrs. - Long acting (i.e. detemir) with onset in 1 hr. and duration of about ...
Mixed dose Combining two kinds of insulin in one injection. A mixed dose commonly combines regular insulin, which is fast acting, with a longer acting insulin such as NPH. A mixed dose insulin schedule may be prescribed to provide both short-term and long-term coverage. mmol/L Millimoles per litre.
Basal insulin: the insulin that controls blood glucose levels between meals and overnight. It controls glucose in the fasting state. Boluses: the insulin that is released when food is eaten or to correct a high reading. Another device used in intensive insulinotherapy is the injection port. An injection port is a small disposable device ...
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In a normal person the blood glucose level is corrected (and may even be slightly over-corrected) by the end of the test. An insulin spike is a 'first response' to blood glucose increase, this response is individual and dose specific although it was always previously assumed to be food type specific only.
“That’s a big dose in one drink; that’s three-quarters of the way to the legal limit,” he said. “That’s enough to keep someone at a positive blood alcohol level almost four hours once ...
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