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Cirrhosis can take quite a long time to develop, and symptoms may be slow to emerge. [13] Some early symptoms include tiredness, weakness, loss of appetite, weight loss, and nausea. [13] Early signs may also include redness on the palms known as palmar erythema. [11] People may also feel discomfort in the right upper abdomen around the liver. [13]
It frequently occurs in the setting of liver failure, cirrhosis, diabetes mellitus, congestive heart failure, hyperthyroidism, or malnutrition. Eighty percent of patients with severe liver disease have Terry's nails, but they are also found in people with kidney failure, in patients with congestive heart failure [ 4 ] and are described as a ...
Cirrhosis, especially in primary biliary cholangitis [9] Hepatopulmonary syndrome, a complication of cirrhosis [10] Others: Graves' disease (autoimmune hyperthyroidism) – in this case it is known as thyroid acropachy [11] Familial and hereditary clubbing and "pseudoclubbing" (people of African descent often have what appears to be clubbing)
Alcohol-related cirrhosis [17] Film director Chögyam Trungpa: 4 April 1987 (aged 48) Halifax, Nova Scotia: Alcoholism, alcohol-related liver cirrhosis, cardiac arrest: Buddhist meditation master George Brown: 2 June 1985 (aged 70) Truro, Cornwall, England Cirrhosis, stroke [18] Politician Ian Hendry: 24 December 1984 (aged 53)
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Although HCV was not discovered until April 1989, [3] an estimated 170 million people worldwide are infected by hepatitis C. [4] As of April 2014, 130—150 million globally suffer from chronic hepatitis C infection; a significant number develop cirrhosis of the liver or liver cancer. Each year, 350,000 to 500,000 people die from hepatitis C ...
Chronic liver failure usually occurs in the context of cirrhosis, itself potentially the result of many possible causes, such as excessive alcohol intake, hepatitis B or C, autoimmune, hereditary and metabolic causes (such as iron or copper overload, steatohepatitis or non-alcoholic fatty liver disease). [citation needed]
Cirrhosis is a late stage of serious liver disease marked by inflammation (swelling), fibrosis (cellular hardening) and damaged membranes preventing detoxification of chemicals in the body, ending in scarring and necrosis (cell death). [11] Between 10% and 20% of heavy drinkers will develop cirrhosis of the liver (NIAAA, 1993).
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