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  2. Diazepam - Wikipedia

    en.wikipedia.org/wiki/Diazepam

    The elimination half-life of diazepam and also the active metabolite desmethyldiazepam increases significantly in the elderly, which may result in prolonged action, as well as accumulation of the drug during repeated administration. [113]

  3. Effects of long-term benzodiazepine use - Wikipedia

    en.wikipedia.org/wiki/Effects_of_long-term...

    In the elderly, long-term benzodiazepine therapy is a risk factor for amplifying cognitive decline, [29] although gradual withdrawal is associated with improved cognitive status. [30] A study of alprazolam found that 8 weeks administration of alprazolam resulted in deficits that were detectable after several weeks but not after 3.5 years. [31]

  4. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.

  5. Benzodiazepine withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_withdrawal...

    The elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals. Many doctors do not adjust benzodiazepine dosage according to age in elderly patients. [137]

  6. Doctors Say This Nighttime Behavior Can Be A Sign Of Dementia

    www.aol.com/doctors-nighttime-behavior-sign...

    Here's how to distinguish "sundowning"—agitation or confusion later in the day in dementia patients—from typical aging, from doctors who treat older adults.

  7. Celine Dion Recalls Taking Up to 90 Milligrams of Valium Amid ...

    www.aol.com/entertainment/celine-dion-recalls...

    Celine Dion is getting candid about her health. In an interview with Hoda Kotb on Tuesday -- portions of which aired on the Today show ahead of the scheduled primetime special -- the 56-year-old ...

  8. Celine Dion Took Potentially Fatal Dosages of Valium to Cope ...

    www.aol.com/celine-dion-took-potentially-fatal...

    Dion, who was taking Valium so she could perform, gradually built a tolerance and at one point was taking 90 milligrams a day — far beyond the maximum recommended dosage of 40 milligrams.

  9. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    Long-acting compounds have a half-life of 40–250 hours. They have a risk of accumulation in the elderly and in individuals with severely impaired liver function, but they have a reduced severity of rebound effects and withdrawal. Examples are diazepam, clorazepate, chlordiazepoxide, and flurazepam.

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