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  2. Diltiazem - Wikipedia

    en.wikipedia.org/wiki/Diltiazem

    For supraventricular tachycardias , diltiazem appears to be as effective as verapamil in treating re-entrant supraventricular tachycardia. [17] Atrial fibrillation [18] or atrial flutter is another indication. The initial bolus should be 0.25 mg/kg, intravenous (IV). Because of its vasodilatory effects, diltiazem is useful for treating ...

  3. Pantoprazole - Wikipedia

    en.wikipedia.org/wiki/Pantoprazole

    Use in pregnancy appears to be safe. [5] Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. [5] It works by inactivating (H+/K+)-ATPase function in the stomach. [9] [5] The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [10] It is available as a generic medication.

  4. Effective dose (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Effective_dose_(pharmacology)

    In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [ 1 ] [ 2 ] The term "effective dose" is used when measurements are taken in vivo , while "effective concentration" is used when the measurements are taken in vitro .

  5. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    Classically, for clinical indications of an approved drug, TI refers to the ratio of the dose of the drug that causes adverse effects at an incidence/severity not compatible with the targeted indication (e.g. toxic dose in 50% of subjects, TD 50) to the dose that leads to the desired pharmacological effect (e.g. efficacious dose in 50% of ...

  6. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    0.5: 0.5–2: 2: hypnotic: Drug Name Common Trade Names Year Approved Typical Dosages of Oral Tablets (mg) Approx. Equivalent Oral Dose to 10mg Diazepam (mg) Peak onset of action (hours) Elimination Half-life of Active Metabolite (hours) Primary Therapeutic Use

  7. Therapeutic drug monitoring - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_drug_monitoring

    TDM interpretation: an anticancer drug is given to a patient at a dosage of 400 mg every day at 8:00 am. A TDM sample is obtained at 6:00 am, showing a drug concentration of 0.46 mg/L. 1) Regarding “normality”, the result is around the 25th percentile, suggesting a rather high drug clearance in this patient.

  8. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.

  9. Commonly prescribed drugs - Wikipedia

    en.wikipedia.org/wiki/Commonly_prescribed_drugs

    If the maximum dose of statin cannot achieve the patient's goal, combination with ezetimibe is recommended. [17] An image of rosuvastatin tablets (Crestor) Caution. Atorvastatin and simvastatin are metabolized by CYP450 enzymes, leading to CYP450 enzymes related potential drug interactions; Contraindications. Active liver disease; Pregnancy or ...

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