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Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic , nodular lesions, which commonly appear on the trunk, arms and legs. [1] Patients often present with multiple excoriated nodules caused by chronic scratching.
Xerosis is a contributing factor to pruritus and is present in 50–85% of patients with uremic pruritus. [16] Many studies have shown that emollients such as glycerol and paraffin, [17] physiological lipids, [18] 10% urea and dexpanthenol, [19] and baby oil [20] can reduce xerosis and pruritus in patients with uremic pruritus.
The efficacy and safety of dupilumab to treat prurigo nodularis among adults were evaluated in two clinical trials, EFC16459 (PRIME) and EFC16460 (PRIME2). [10] Each trial evaluated 300 mg of dupilumab administered every 2 weeks following an initial dose of 600 mg. [ 10 ] The treatment lasted for 24 weeks. [ 10 ]
Actinic prurigo (familial polymorphous light eruption of American Indians, hereditary polymorphous light eruption of American Indians, Hutchinson's summer prurigo, hydroa aestivale) Aerosol burn; Benign summer light eruption; Beryllium granuloma
Prurigo is a reactive skin condition distinguished by numerous, isolated itchy papules. [1] The word "prurigo" comes from the Latin word pruire, which meaning itching. Ferdinand von Hebra coined the term "prurigo" in Vienna in 1850 to describe papules and nodules that had severe pruritus . [ 2 ]
Chronic scratching of lesions can cause thickening or lichenification of the skin or prurigo nodularis (generalized nodules that are severely itchy). [34] Another factor in the barrier failure and immunological dysregulation in people with atopic dermatitis may be due to decreases in tight junction protein Claudin-1.
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