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Resminostat (4SC-201 or RAS2410) is an orally bioavailable inhibitor of histone deacetylases (HDACs), of which inhibitors are antineoplastic agents. [1]In 2011, the German drug maker 4SC was granted orphan drug designation for resminostat by the US FDA for the treatment of hepatocellular carcinoma (HCC).
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145 251.75 g·mol −1 Datopotamab deruxtecan , sold under the brand name Datroway , is an anti-cancer medication used for the treatment of breast cancer . [ 1 ] [ 2 ] It is a Trop-2 -directed antibody and topoisomerase inhibitor antibody-drug conjugate .
Etaracizumab, also known as MEDI-522, trade name Abegrin, is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer, [1] ovarian cancer [2] and various other types of cancer. [3] It is manufactured by MedImmune. [1] It is an enhanced iteration of Vitaxin, also known as MEDI-523 ...
The fully human IgG2 monoclonal antibody glembatumumab (CR011) is linked to monomethyl auristatin E (MMAE). [citation needed] It uses a valine-citrulline enzyme-cleavable linker. [2] The linkage is stable in the bloodstream. The antibody binds to GPNMB on the cancer cells, the ADC is internalised, the linkage is broken and MMAE is released to ...
Wolfgang Kaim (born 13 May 1951 in Bad Vilbel, Germany) is a German chemist who held the chair of coordination chemistry at the University of Stuttgart.He is co-author of the internationally recognized book, Bioinorganic Chemistry which was awarded with the Literature Award of the German Chemical Industry.
Cardiff's career began as an intern at Kings County Hospital Center in Brooklyn, NY, in 1962-1963. He served in the U.S. Army Medical Corps at the Walter Reed Army Institute of Research, being discharged with the rank of Lieutenant Colonel.