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The vascular (blood) system can be affected by solid tumors. Between 15 and 25 percent of deep vein thrombosis is caused by cancer (often by a tumor compressing a vein), and it may be the first hint that cancer is present. It causes swelling and pain in the legs, especially the calf, and (rarely) in the arms. [19]
Acute hemorrhage into a hepatocellular carcinoma causes severe upper right quadrant pain, and may be life-threatening, requiring emergency surgery or other emergency intervention. [5] A tumor can expand the size of the liver several times and consequent stretching of its capsule can cause aching pain in the right hypochondrium.
The pain can be debilitating and prevent one from doing activities that they would normally do as part of their daily routine. OA typically affects the weight-bearing joints, such as the back, knee and hip due to the mechanical nature of this disease process. Unlike rheumatoid arthritis, osteoarthritis is most commonly a disease of the elderly.
Osteoarthritis commonly affects the hands, feet, spine, and the large weight-bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. As osteoarthritis progresses, movement patterns (such as gait), are typically affected. [1] Osteoarthritis is the most common cause of a joint effusion of the knee. [15]
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Cartilage in the knee may begin to break down after sustained stress, leaving the bones of the knee rubbing against each other and resulting in osteoarthritis. [7] Nearly a third of US citizens are affected by osteoarthritis of the knee by age 70. [8] Obesity is a known and very significant risk factor for the development of osteoarthritis. [9]
This initial inflammation and pain eventually subsides, and the patient is left with a permanent bony outgrowth that often skews the fingertip sideways. Bouchard's nodes may also be present; these are similar bony growths in the proximal interphalangeal (PIP) joints (middle joints of the fingers), and are also associated with osteoarthritis.
Chronic systemic inflammation is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...
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