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o-Toluidine is absorbed through inhalation and dermal contact as well as from the gastrointestinal tract. [19] [13] [20] [21]The metabolism of o-toluidine involves many competing activating and deactivating pathways, including N-acetylation, N-oxidation, and N-hydroxylation, and ring oxidation.
2-Tolidine (orthotolidine, o-tolidine; not to be confused with o-toluidine) is an organic compound with the chemical formula (C 6 H 4 (CH 3)NH 2) 2. Several isomers are known; the 3-tolidine derivative is also important commercially. It is a colorless compound although commercial samples are often colored. It is slightly soluble in water.
The other toluidine isomers are used in the production of dyes. They are a component of accelerators for cyanoacrylate glues. In some patients o-toluidine is a metabolite of prilocaine, which may cause methemoglobinemia. This is then treated with methylene blue.
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Older children and adults should take frequent sips from a cup, with a recommended intake of 200–400 mL of solution after every loose movement. [1] The WHO recommends giving children under two a quarter- to a half-cup of fluid following each loose bowel movement and older children a half- to a full cup.
A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex ...
Fluid replacement or fluid resuscitation is the medical practice of replenishing bodily fluid lost through sweating, bleeding, fluid shifts or other pathologic processes. . Fluids can be replaced with oral rehydration therapy (drinking), intravenous therapy, rectally such as with a Murphy drip, or by hypodermoclysis, the direct injection of fluid into the subcutaneous tis
The typical adult dose is one 130 mg tablet per 24 hours, supplying 100 mg (100,000 micrograms) of ionic iodine (the typical daily dose of iodine for normal health is on the order of 100 micrograms). Ingestion of this large dose of non-radioactive iodine minimises the uptake of radioactive iodine by the thyroid gland.