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NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [ 5 ] [ 6 ] [ 7 ] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
In yeast, roundworms, and fruitflies, sir2 is the name of one of the sirtuin-type proteins (see table below). [16] Mammals possess seven sirtuins (SIRT1–7) that occupy different subcellular compartments: SIRT1, SIRT6 and SIRT7 are predominantly in the nucleus, SIRT2 in the cytoplasm, and SIRT3, SIRT4 and SIRT5 in the mitochondria. [2]
SRT-1720 is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and efficacy in humans have not been established.
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Remains from all 67 victims of the midair collision over Washington, D.C., that sent an American Airlines regional plane and an Army Black Hawk helicopter crashing into the Potomac River have been ...
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic compounds that may be helpful in treating various aging -related diseases.
The Baseball Hall of Fame Class of 2025 has been decided. Outfielder Ichiro Suzuki, pitcher CC Sabathia and reliever Billy Wagner have all been elected, each earning at least 75% of votes from ...
SIR proteins organize heterochromatin near telomeres, [1] ribosomal DNA (rDNA), [2] and at silent loci including hidden mating type loci in yeast. [ 3 ] [ 4 ] The SIR family of genes encodes catalytic and non-catalytic proteins that are involved in de-acetylation of histone tails and the subsequent condensation of chromatin around a SIR protein ...