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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Most sources still use the term "centrally acting muscle relaxant". According to MeSH, dantrolene is usually classified as a centrally acting muscle relaxant. [9] The World Health Organization, in its ATC, uses the term "centrally acting agents", [10] but adds a distinct category of "directly acting agents", for dantrolene. [11]
Baclofen, diazepam and dantrolene remain the three most commonly used pharmacologic agents in the treatment of spastic hypertonia. Baclofen is generally the drug of choice for spinal cord types of spasticity, while sodium dantrolene is the only agent which acts directly on muscle tissue. Tizanidine is also available.
A physiotherapist can help to reduce spasticity and avoid the development of contractures with techniques such as passive stretching. [166] Nabiximols is safe and effective for relieving spasticity. [167] There is evidence, albeit limited, of the clinical effectiveness of baclofen, [168] dantrolene, [169] diazepam, [170] and tizanidine.
The treatment of spasticity ranges from physical activity to medication. Physical activity includes stretching, aerobic exercises and relaxation techniques. Currently, there is little understanding as to why these physical activities aid in relieving spasticity. Medical treatments include baclofen, diazepam and dantrolene which is a muscle ...
Every helpful hint and clue for Sunday's Strands game from the New York Times.
Oral medications used for the treatment of spasticity include: diazepam (Valium), dantrolene sodium, baclofen, tizanidine, clonidine, gabapentin, [59] [61] [62] and even cannabinoid-like compounds.³ The exact mechanism of these medications is not fully understood, but they are thought to act on neurotransmitters or neuromodulators within the ...
Cameron Diaz is opening up about her return to acting.. During the Jan. 17 episode of The Graham Norton Show, the actress, 52, appeared alongside her Back in Action costar Jamie Foxx to discuss ...
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