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Drugs or pharmaceutical agents inducing ototoxicity are regarded as ototoxic medications. Anatomy of the human ear There is a wide range of ototoxic medications, for example, antibiotics , antimalarials , chemotherapeutic agents , non-steroidal anti-inflammatory drugs (NSAIDs) and loop diuretics . [ 2 ]
Ototoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. [1]
This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources .
The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic. Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing. However, these classifications are based on laboratory behavior.
The incidence of inner ear toxicity varies from 7 to 90%, depending on the types of antibiotics used, susceptibility of the patient to such antibiotics, and the duration of antibiotic administration. [20] Another serious and disabling side effect of aminoglycoside use is vestibular ototoxicity. [19]
Amikacin can cause neurotoxicity if used at a higher dose or for longer than recommended. The resulting effects of neurotoxicity include vertigo, numbness, tingling of the skin (paresthesia), muscle twitching, and seizures. [9] Its toxic effect on the 8th cranial nerve causes ototoxicity, resulting in loss of balance and, more commonly, hearing ...
Bottom line: Most drugs carry a risk, but if you've been prescribed an oral or injected fluoroquinolone and you're concerned about side effects, be sure to talk to your doctor about switching.
Some affected people acquire hyperacusis suddenly as a result of taking ototoxic drugs (which can damage the cells responsible for hearing), Lyme disease, Ménière's disease, head injury, or surgery. Others are born with sound sensitivity or develop superior canal dehiscence syndrome. [32]