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Atezolizumab, sold under the brand name Tecentriq among others, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), hepatocellular carcinoma and alveolar soft part sarcoma, [9] [11] but discontinued for use in triple-negative breast cancer (TNBC). [12]
The subcutaneous injection of atezolizumab and hyaluronidase was evaluated in IMscin001 (NCT03735121), an open-label, multi-center, international, randomized trial in adults with locally advanced or metastatic non-small cell lung cancer who were not previously exposed to cancer immunotherapy and who had disease progression following treatment with platinum-based chemotherapy. [2]
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The study enrolled 34 patients, 28 of which underwent surgery to resect the PDAC. 19 of the patients who had undergone surgery then received atezolizumab, an immune checkpoint inhibitor. 16 of the patients on atezolizumab then received autogene cevumeran. 1 patient was considered to have insufficiently many neoantigens to manufacture the vaccine.
PD-1 and PD-L1 inhibitors act to inhibit the association of the programmed death-ligand 1 with its receptor, programmed cell death protein 1 (PD-1). The interaction of these cell surface proteins is involved in the suppression of the immune system and occurs following infection to limit the killing of bystander host cells and prevent autoimmune ...
[52] [16] Atezolizumab for first-line treatment of metastatic NSCLC with PD-L1 ≥ 50% was approved recently by the FDA, [16] after the IMPOWER110 trial showed a median OS of 20.2 months for patients in the atezolizumab arm, compared with 13.1 months in the chemotherapy arm (p = 0.0106). [53]
Under the Serbian system of administration, Kosovo is divided into five districts comprising 28 municipalities and 1 city. In 2000, UNMIK established a system with 7 districts [citation needed] and 30 municipalities. Serbia has not exercised effective control over Kosovo since 1999. For the UNMIK created districts of Kosovo, see Districts of ...
Roche therapy helps 24 percent of untreated bladder cancer patients: study says "At a list price of $12,500 per month, Tecentriq costs roughly the same as [PD-1 inhibitors] Keytruda and Bristol's rival Opdivo" - Should we mention cost here and /or in PD-L1 inhibitors ? - Rod57 09:11, 13 June 2016 (UTC)