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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
CA-125: Mainly ovarian cancer, [12] but may also be elevated in for example endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. [13] Calcitonin: medullary thyroid carcinoma [14] Calretinin: mesothelioma, sex cord-gonadal stromal tumor, adrenocortical carcinoma, synovial sarcoma [8] Carcinoembryonic ...
In patients with diabetes, the CAC score helps identify the individuals most at risk, who could benefit from screening for silent ischemia and from more aggressive clinical treatment. [ 2 ] However, coronary CT angiography (CTA) is superior to coronary CT calcium scanning in determining the risk of Major Adverse Cardiac Events (MACE).
Patient type Lower limit Upper limit Unit Dihydrotestosterone: adult male: 30 85: ng/dL Testosterone: Male, overall: 8, [89] 10 [90] 27, [89] 35 [90] nmol/L 230, [91] 300 [92] 780–1000 [91] [92] ng/dL Male < 50 years: 10 [5] 45 [5] nmol/L 290 [91] 1300 [91] ng/dL Male > 50 years: 6.2 [5] 26 [5] nmol/L 180 [91] 740 [91] ng/dL Female: 0.7 [90 ...
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The one biomarker that has been in use over the last 20 years is CA-125. [121] A 2016 review found that this biomarker was present in those with symptoms of endometriosis; and, once ovarian cancer has been ruled out, a positive CA-125 may confirm the diagnosis. [122] Its performance in ruling out endometriosis is low. [122]
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CA 15-3, for Carcinoma Antigen 15-3, is a tumor marker for many types of cancer, most notably breast cancer. [1] [2] [3]It is derived from MUC1. [4] CA 15-3 and associated CA 27-29 are different epitopes on the same protein antigen product of the breast cancer-associated MUC1 gene.