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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
CA-125: Mainly ovarian cancer, [12] but may also be elevated in for example endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. [13] Calcitonin: medullary thyroid carcinoma [14] Calretinin: mesothelioma, sex cord-gonadal stromal tumor, adrenocortical carcinoma, synovial sarcoma [8] Carcinoembryonic ...
Radiation proctitis can be found in 0.5–21.4% of patients who received prostate brachytherapy due to the proximity of the prostate and the large bowel, with significant injury occurring in 1–2.4% of patients. [citation needed] erectile dysfunction (difficulty getting and/or keeping an erection; impotence).
The one biomarker that has been in use over the last 20 years is CA-125. [121] A 2016 review found that this biomarker was present in those with symptoms of endometriosis; and, once ovarian cancer has been ruled out, a positive CA-125 may confirm the diagnosis. [122] Its performance in ruling out endometriosis is low. [122]
Iodine-125 (125 I) is a radioisotope of iodine which has uses in biological assays, nuclear medicine imaging and in radiation therapy as brachytherapy to treat a number of conditions, including prostate cancer, uveal melanomas, and brain tumors. It is the second longest-lived radioisotope of iodine, after iodine-129.
A case reported in 2013, involves a 50-year-old male with a history of low testosterone levels, high cholesterol and the congenital absence of his right testis. [13] Imaging revealed that the patient had three cystic masses, with structures similar to the uterus and ovaries, thus PMDS. [13]
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TAG-72 is a tumor marker measured with radioimmunoassays like CA 72-4, which uses the monoclonal antibodies indium (111 In) satumomab pendetide and iodine (125 I) ...
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