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Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group. [5] It is prescribed for nausea and vomiting due to motion sickness [6] or other sources such as chemotherapy, [7] vertigo, [8] or Ménière's disease. [9] Cinnarizine is one of the leading causes of drug-induced parkinsonism. [5]
The drug, suzetrigine, received the FDA's official stamp of approval Thursday to be sold as a 50-milligram prescription pill taken every 12 hours, according to a press release.
"Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study". Clin Ther . 26 (6): 866– 77.
However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death. In 2013, benzodiazepines were involved in 31% of the estimated 22,767 deaths from prescription drug overdose in the United States. [5]
The DSM-5 defines alcohol intoxication as at least one of the following symptoms that developed during or close after alcohol ingestion: slurred speech, incoordination, unsteady walking/movement, nystagmus (uncontrolled eye movement), attention or memory impairment, or near unconsciousness or coma. [16]
In 2018, emergency shelters in the county served about 9,200 adults and children, and a one-night count in January 2019 estimated 1,907 people either in shelters or on the streets. In 2019, the Dispatch reported on the city's policy of dismantling homeless camps, displacing its residents without a plan to re-house them. [ 6 ]
Sedation is very common, and extrapyramidal side effects are common and include restlessness, dystonic reactions, pseudoparkinsonism, and akathisia; the extrapyramidal symptoms can affect 2% of people at low doses, whereas higher doses may affect as many as 40% of people.
Flunarizine is a selective calcium antagonist with moderate other actions including antihistamine, serotonin receptor blocking and dopamine D 2 blocking activity. Compared to other calcium channel blockers such as dihydropyridine derivatives, verapamil and diltiazem, flunarizine has low affinity to voltage-dependent calcium channels.
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