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  2. Insulin signal transduction pathway - Wikipedia

    en.wikipedia.org/wiki/Insulin_signal...

    Several hormones can affect insulin secretion. Estrogen is correlated with an increase of insulin secretion by depolarizing the β-cells membrane and enhancing the entry of Ca 2+. In contrast, growth hormone is known to lower the serum level of insulin by promoting the production of insulin-like growth factor-I (IGF-I).

  3. Beta cell - Wikipedia

    en.wikipedia.org/wiki/Beta_cell

    The triggering pathway of glucose-stimulated insulin secretion. In beta cells, insulin release is stimulated primarily by glucose present in the blood. [4] As circulating glucose levels rise such as after ingesting a meal, insulin is secreted in a dose-dependent fashion. [4] This system of release is commonly referred to as glucose-stimulated ...

  4. Insulin - Wikipedia

    en.wikipedia.org/wiki/Insulin

    Parasympathetic stimulation of the pancreatic islets operates via this pathway to increase insulin secretion into the blood. [56] The significantly increased amount of calcium ions in the cells' cytoplasm causes the release into the blood of previously synthesized insulin, which has been stored in intracellular secretory vesicles.

  5. Gastric inhibitory polypeptide - Wikipedia

    en.wikipedia.org/wiki/Gastric_inhibitory_polypeptide

    Gastric inhibitory polypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone of the secretin family of hormones. [5] While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion.

  6. Paracrine regulator - Wikipedia

    en.wikipedia.org/wiki/Paracrine_regulator

    Alpha cells in the pancreatic islet release glucagon, a hormone that regulates blood glucose levels antagonistically to insulin by stimulating the breakdown of glycogen stores to increase glucose concentrations in the bloodstream. [4] However, glucagon can also activate receptors on pancreatic beta cells to increase insulin secretion.

  7. Blood sugar regulation - Wikipedia

    en.wikipedia.org/wiki/Blood_sugar_regulation

    1) Induce insulin secretion 2) Inhibits apoptosis of the pancreatic beta cells and promotes their proliferation 3) Stimulates glucagon secretion and fat accumulation Lowers Glucagon: Pancreatic α Cells: 1) Enhances release of glucose from glycogen (glycogenolysis); 2) Enhances synthesis of glucose (gluconeogenesis) from amino acids or fats. Raises

  8. Glucokinase - Wikipedia

    en.wikipedia.org/wiki/Glucokinase

    Glucokinase in beta cells serves as a glucose sensor, amplifying insulin secretion as blood glucose rises. In the pancreatic beta-cell, glucokinase is a key regulator enzyme. Glucokinase is very important in the regulation of insulin secretion and has been known as the pancreatic beta-cell sensor.

  9. Glucagon-like peptide-1 receptor - Wikipedia

    en.wikipedia.org/wiki/Glucagon-like_peptide-1...

    When glucose is not present, this receptor no longer couples to stimulate insulin secretion in order to prevent hypoglycemia. [ 24 ] Relating glucose metabolism and insulin sensitivity back to Huntington's disease, increased insulin release and beta cell proliferation by a GLP-1 agonist, Ex-4, helps combat the damage done by mutant htt in ...

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