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The effect of these structural changes on behavior is uncertain and studies have produced conflicting results. Two studies [ 18 ] [ 19 ] have shown that an increase in dendritic spine density due to cocaine exposure facilitates behavioral sensitization , while two other studies [ 20 ] [ 21 ] produce contradicting evidence.
It was also found that the H3 acetylation induced by cocaine increased Sirt1 in the nucleus accumbens. Thus, repeated cocaine use causes an increase in both Sirt1 and Sirt2. Scientists were then interested in determining how increased Sirt1 and Sirt2 affected nuclear volume because it has been previously shown that repeated cocaine use does so ...
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [193] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
Monoamine transporters are established targets for many pharmacological agents that affect brain function, including the psychostimulants cocaine and amphetamine. Cocaine and amphetamine employ different mechanisms that both result in an increase in extracellular monoamines by decreasing reuptake.
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[246] [247] Nevertheless, the number of cocaine users remain high, with a large concentration among urban youth. In addition to the amounts previously mentioned, cocaine can be sold in "bill sizes": As of 2007 for example, $10 might purchase a "dime bag", a very small amount (0.1–0.15 g) of cocaine. These amounts and prices are very popular ...
How does pink cocaine affect someone? It can be hard to determine how the drug cocktail may affect someone after ingesting it. WebMD said this is due to several factors: the types of drugs mixed ...
Cocaine has a similar potential to induce temporary psychosis [21] with more than half of cocaine abusers reporting at least some psychotic symptoms at some point. [22] Typical symptoms include paranoid delusions that they are being followed and that their drug use is being watched, accompanied by hallucinations that support the delusional ...