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The Global Buruli Ulcer Initiative (GBUI) is a World Health Organization (WHO) initiative to coordinate global efforts to control Buruli ulcer, [1] an infectious disease characterized by the development of painless open wounds. [2]
In 1998, the World Health Organization started the Global Buruli Ulcer Initiative with the aim of coordinating global efforts to control the disease. [47] This was followed in 2004 by World Health Organization Resolution WHA57.1 calling upon member countries to support the Global Buruli Ulcer Initiative and increase research on Buruli ulcer ...
Buruli ulcer is caused by the bacterium Mycobacterium ulcerans. [34] It is related to the bacteria that cause tuberculosis and leprosy. Mycobacterium ulcerans produces a toxin, mycolactone, that destroys tissue. [34] The prevalence of Buruli ulcer is unknown. [18] The risk of mortality is low, although secondary infections can be lethal. [35]
Deep ulcers can cause scarring of muscles and tendons, resulting in permanent disability. Buruli ulcer is caused by skin infection with bacteria called Mycobacterium ulcerans . The mechanism by which M. ulcerans is transmitted from the environment to humans is not known, but may involve the bite of an aquatic insect or the infection of open wounds.
Mycolactone is a polyketide-derived macrolide produced and secreted by a group of very closely related pathogenic mycobacteria species including M. ulcerans, M. liflandii (an unofficial designation), M. pseudoshottsii, and some strains of M. marinum.
One surprising finding of the 2016 Global Burden of Disease study is that India has the most and worst cases of 11 of the 16 neglected tropical diseases it considered. [1] India has the most cases of all neglected tropical diseases which occur in India.
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George Institute for Global Health; Global Alliance for Improved Nutrition; Global Alliance on Health and Pollution; Global Burden of Disease Study; Global Buruli Ulcer Initiative; Global Business Brigades; Global Child Development Group; Global Forum for Health Research; The Global Fund to Fight AIDS, Tuberculosis and Malaria; Global ...