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The artificial sweetener aspartame has been the subject of several controversies since its initial approval by the U.S. Food and Drug Administration (FDA) in 1974. The FDA approval of aspartame was highly contested, beginning with suspicions of its involvement in brain cancer, [1] alleging that the quality of the initial research supporting its safety was inadequate and flawed, and that ...
Aspartame is an artificial non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. [4] 200 times sweeter than sucrose, it is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSweet, Equal, and Canderel. [4]
November 2005 Online publication of Soffritti "First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats" [10] "The results of this mega-experiment indicate that [aspartame] is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake."
In 2000, the line was reformulated yet again, this time to replace aspartame with Splenda brand sucralose and Sunett brand acesulfame potassium. It became the first major diet soda in the United States to use neither aspartame nor saccharin as a sweetener. In 2005, "Pure Zero" was added to the name, and a cherry cola flavor was introduced in 2006.
The FDA approved aspartame's use in soft drinks in November 1983, and Pepsi was among the first brands to deploy the product on a large scale in the United States. When G. D. Searle was acquired by Monsanto in 1985, Shapiro moved up the management chain in the ladder, becoming Vice President in 1990, President in 1993 and CEO in 1995.
Aspartame was invented by chemists at G. D. Searle & Company in 1965. [2] Searle was bought by Monsanto in 1985. [ 3 ] In March 2000, Monsanto, which was then a subsidiary of the Pharmacia corporation, sold NutraSweet to the private equity firm J.W. Childs Associates . [ 2 ]
Acesulfame potassium is usually combined with aspartame, sucralose, or saccharin rather than alone and its use is particularly common among smaller beverage producers (e.g. Big Red). Diet Rite is the non-aspartame diet soft drink brand with the highest sales today; it uses a combination of sucralose and acesulfame potassium. [citation needed]
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