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It is caused by cigarette smoking. [1] [2] The term SRIF was coined by Dr. Anna-Luise Katzenstein (a pathologist) and colleagues in 2010 in a study of lung specimens surgically removed for lung cancer. [3] Since then, other investigators have confirmed the same abnormality in the lungs of a subset of smokers. [4] [5]
Cigarettes are known to cause many lung diseases including emphysema, chronic bronchitis, and lung cancer. Smoker's macrophages are alveolar macrophages whose characteristics, including appearance, cellularity, phenotypes, immune response, and other functions, have been affected upon the exposure to cigarettes. [1]
It is commonly caused by tobacco smoking but some people are affected who have never smoked. [14] The presence of emphysema is a clear risk factor for lung cancer, made stronger in those who smoke. [20] Early symptoms of emphysema vary.
Respiratory bronchiolitis is a lung disease associated with tobacco smoking. [1] In pathology, it is defined by the presence of "smoker's macrophages". [1] When manifesting significant clinical symptoms it is referred to as respiratory bronchiolitis interstitial lung disease (RB-ILD). [1]
Cigarette smoking can increase the risk or make the illness worse. [7] Smoking is a known cause of some types of lung fibrosis, such as smoking-related interstitial fibrosis (SRIF). [11] Some typical connective tissue diseases [7] such as rheumatoid arthritis, ankylosing spondylitis, SLE and scleroderma
Desquamative interstitial pneumonia (DIP) is a type of idiopathic interstitial pneumonia featuring elevated numbers of macrophages within the alveoli of the lung. [1] DIP is a chronic disorder with an insidious onset. Its common symptoms include shortness of breath, coughing, fever, weakness, weight loss, and fatigue.
Combined pulmonary fibrosis and emphysema (CPFE), describes a medical syndrome involving both pulmonary fibrosis and emphysema. [ 1 ] [ 2 ] The combination is most commonly found in male smokers. Pulmonary function tests typically show preserved lung volume with very low transfer factor.
Patients may watch for symptoms, such as shortness of breath, change in character or amount of mucus, and start self-treatment as discussed with a health care provider. This allows for treatment right away until a doctor can be seen. [5] The symptoms of acute exacerbations are treated using short-acting bronchodilators.
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