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Dihydroxyacetone phosphate (DHAP, also glycerone phosphate in older texts) is the anion with the formula HOCH 2 C(O)CH 2 OPO 3 2-. This anion is involved in many metabolic pathways , including the Calvin cycle in plants and glycolysis .
Dihydroxyacetone (/ ˌ d aɪ h aɪ ˌ d r ɒ k s i ˈ æ s ɪ t oʊ n / ⓘ; DHA), also known as glycerone, is a simple saccharide (a triose) with formula C 3 H 6 O 3. DHA is primarily used as an ingredient in sunless tanning products. It is often derived from plant sources such as sugar beets and sugar cane, and by the fermentation of glycerin.
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases.The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclic FMN) from FAD.
Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate (a.k.a. glycerone phosphate, outdated) to sn-glycerol 3-phosphate. [2] Glycerol-3-phosphate dehydrogenase serves as a major link between carbohydrate metabolism and lipid metabolism.
This enzyme acylates dihydroxyacetone phosphate at the sn-1 position. This is followed by the exchange of the acyl group for an alkyl group by AGPS. [ 15 ] The 1-alkyl-DHAPdihydroxyacetone phosphate is then reduced to 1-O-alkyl-2-hydroxy-sn-glycerophosphate (GPA) by an acyl/alkyl-dihydroxyacetone phosphate reductase located in both peroxisomal ...
21991 Ensembl ENSG00000111669 ENSMUSG00000023456 UniProt P60174 P17751 RefSeq (mRNA) NM_001258026 NM_000365 NM_001159287 NM_009415 RefSeq (protein) NP_000356 NP_001152759 NP_001244955 NP_033441 Location (UCSC) Chr 12: 6.87 – 6.87 Mb Chr 6: 124.79 – 124.79 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Triosephosphate isomerase is an enzyme that in humans is encoded by the TPI1 ...
The structure of TPI facilitates the conversion between dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (GAP). The nucleophilic glutamate 165 residue of TPI deprotonates the substrate , [ 4 ] and the electrophilic histidine 95 residue donates a proton to form the enediol intermediate.
The first reaction is the oxidation of glyceraldehyde 3-phosphate (G3P) at the position-1 (in the diagram it is shown as the 4th carbon from glycolysis), in which an aldehyde is converted into a carboxylic acid (ΔG°'=-50 kJ/mol (−12kcal/mol)) and NAD+ is simultaneously reduced endergonically to NADH.