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EPOCH is an intensive chemotherapy regimen intended for treatment of aggressive non-Hodgkin's lymphoma. [1] [2] It is often combined with rituximab. In this case it is called R-EPOCH or EPOCH-R. The R-EPOCH regimen consists of: Rituximab: an anti-CD20 monoclonal antibody, which has the ability to kill B cells, be they normal or malignant;
Treatment commonly begins with either R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone) or DA-EPOCH-R (dose-adjusted etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin, rituximab). [14] Other, more intense, regimens may be more effective. [10] PD-1 and PD-L1 inhibitors can be used. [3]
One recommendation for treating these DH/THL cases is the DA-R-EPOCH regimen (dose-adjusted rituximab, etoposide, prednisolone, oncovin, cyclophosphamide, and hydroxydaunorubicin). S-R-EPOCH achieves 2 year survival rates of 40–67% compared to a ~25% survival rate for R-CHOP in these cases. [30]
A few of these regimens are: the GMALL-B-ALL/NHL2002 protocol, the modified Magrath regimen (R-CODOX-M/IVAC). [24] COPADM, [25] hyper-CVAD, [26] and the Cancer and Leukemia Group B (CALGB) 8811 regimen; [26] these can be associated with rituximab. [26] [27] In older patients, treatment may be dose-adjusted EPOCH with rituximab. [28]
Plasmablastic lymphoma lesions are most commonly rapidly growing, soft tissue masses [5] that may be ulcerating, bleeding, and/or painful. [6] In a recent (2020) review of published cases, individuals presenting with PBD were typically middle-aged or elderly (range 1–88 years; median age 58 tears) males (~73% of cases). [7]
DUBAI (Reuters) -Yemen's Iran-aligned Houthis have released the crew of the Galaxy Leader more than a year after they seized the Bahamas-flagged vessel off the Yemeni Red Sea coast, Houthi-owned ...
The definition was refined in 1950 as "that dose of any ionizing radiation which produces a relevant biological effect equal to that produced by one roentgen of high-voltage x-radiation." [ 19 ] Using data available at the time, the rem was variously evaluated as 83, 93, or 95 erg /gram. [ 20 ]
Rep. Jim Walsh, R-Aberdeen, who chairs the Washington State Republican Party, and freshman Rep. Michael Keaton, R-Puyallup, encouraged people to keep showing up and speaking out.