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Lymphocytic pleocytosis is an abnormal increase in the amount of lymphocytes in the cerebrospinal fluid (CSF). It is usually considered to be a sign of infection or inflammation within the nervous system , and is encountered in a number of neurological diseases , such as pseudomigraine, Susac's syndrome, and encephalitis.
In medicine, pleocytosis (or pleiocytosis) is an increased cell count (from Greek pleion, "more"), particularly an increase in white blood cell count, in a bodily fluid, such as cerebrospinal fluid. [1] It is often defined specifically as an increased white blood cell count in cerebrospinal fluid. [2]
Mollaret's meningitis is characterized by chronic, recurrent episodes of headache, stiff neck, meningismus, and fever; cerebrospinal fluid (CSF) pleocytosis with large "endothelial" cells, neutrophil granulocytes, and lymphocytes; and attacks separated by symptom-free periods of weeks to years; and spontaneous remission of symptoms and signs.
Some of the possible symptoms of chronic meningitis (due to any cause) include headache, nausea and vomiting, fever, and visual impairment. Nuchal rigidity (or neck stiffness with discomfort in trying to move the neck), a classic symptom in acute meningitis, was seen in only 45% of cases of chronic meningitis with the sign being even more rare in non-infectious causes.
Similarly, raised CSF protein levels and pleocytosis are frequent but non-specific. It was originally thought [5] that raised CSF protein without pleocytosis ('albuminocytological dissociation') was a characteristic feature, as it is in Guillain–Barré syndrome, but this has not been supported in more recent work. [7]
Laboratory studies that support diagnosis of AHL are: peripheral leukocytosis, cerebrospinal fluid (CSF) pleocytosis associated with normal glucose and increased protein. On magnetic resonance imaging (MRI), lesions of AHL typically show extensive T2-weighted and fluid-attenuated inversion recovery (FLAIR) white matter hyperintensities with ...
Payton Meulemans, 26, recorded the moment she told her twin sister, Rylie Parman, that she is expecting her first child. In a video that now has over 7 million views on TikTok, Parman can be seen ...
lack of initial CSF pleocytosis (i.e. low CSF white blood cell count); elevated C-reactive protein; failure to sterilize the CSF before immune recovery. IRIS may be the cause of paradoxically worse outcomes for cryptococcal meningitis in immunocompetent compared with immunocompromised hosts, in whom Cryptococcus neoformans is the usual pathogen ...