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Second-generation sulfonylureas have increased potency by weight, compared to first-generation sulfonylureas. [21] Similarly, ACCORD (Action to Control Cardiovascular Risk in Diabetes) [ 22 ] and the VADT (Veterans Affairs Diabetes Trial) [ 23 ] studies showed no reduction in heart attack or death in patients assigned to tight glucose control ...
Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. [1] It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehringer Ingelheim (Germany).
It is classified as a second-generation sulfonylurea. [4] Glimepiride was patented in 1979 and approved for medical use in 1995. [5] It is available as a generic medication. [2] In 2022, it was the 64th most commonly prescribed medication in the United States, with more than 10 million prescriptions. [6] [7]
Sulfonylureas: Some of the oldest diabetes drugs in use. Sulfonylureas are among the oldest diabetes medications in use, discovered in 1946 and introduced clinically in 1956. They work by ...
Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. [7] It is used when dietary changes, exercise, and weight loss are not enough. [4] It is taken by mouth. [7] Side effect may include low blood sugar, vomiting, abdominal pain, rash, and liver problems.
The American Association of Clinical Endocrinologists (AACE), which provides clinical practice guidelines for management of diabetes, retains thiazolidinediones as recommended first, second, or third line agents for type 2 diabetes mellitus, as of their 2019 executive summary, over sulfonylureas and α-glucosidase inhibitors.
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