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No cheaper generic alternative is available. Entresto helps manage chronic heart failure by reducing the effort necessary for the heart to pump blood around the body.
It also states the safety of the drug in severe renal impairment has not been established. [7] Valsartan includes a black box warning for fetal toxicity. [7] [9] Discontinuation of these agents is recommended immediately after detection of pregnancy and an alternative medication should be started. [7] Breastfeeding is not recommended. [7] [24] [25]
Sacubitril/valsartan, sold under the brand name Entresto among others, is a fixed-dose combination medication for use in heart failure. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan .
Sacubitril (/ s ə ˈ k juː b ɪ t r ɪ l /; INN) is an antihypertensive drug used in combination with valsartan. The combination drug sacubitril/valsartan, known during trials as LCZ696 and marketed under the brand name Entresto, is a treatment for heart failure. [1] It was approved under the FDA's priority review process for use in heart ...
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Isosorbide dinitrate is available as a generic medication. [1] [5] A long-acting form exists. [1] In 2022, isosorbide was the 119th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [6] [7]