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Chelation (/ k iː ˈ l eɪ ʃ ən /) is a type of bonding of ions and their molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom.
Chelation therapy is a medical procedure that involves the administration of chelating agents to remove heavy metals from the body. [1] Chelation therapy has a long history of use in clinical toxicology [2] and remains in use for some very specific medical treatments, although it is administered under very careful medical supervision due to various inherent risks, including the mobilization of ...
TPEN (N,N,N ′,N ′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine [1]) is an intracellular membrane-permeable ion chelator. [2] TPEN has a high affinity for many transition metals and should not be considered specific or selective for a particular ion. Chelators can be used in chelation therapy to remove toxic metals in the body. TPEN is a ...
DOTA (chelator) derivatives (6 P) S. Sequestrants (1 P) Siderophores (23 P) Pages in category "Chelating agents" The following 164 pages are in this category, out of ...
DOTA is derived from the macrocycle known as cyclen.The four secondary amine groups are modified by replacement of the N-H centers with N-CH 2 CO 2 H groups. The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations.
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DOTAM (also known as TCMC) is an organic compound used as a chelator much like its carboxylic acid analog DOTA. A derivative with a reactive linking group of para-isothiocyanatobenzyl attached to the cyclen ring is also of interest as a bifunctional chelator (BFC).
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