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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
[citation needed] The great majority of drugs on the market have molecular weights between 200 and 600 daltons, and particularly <500; [3] [4] they belong to the group of small molecules. A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five , which covers the numbers of hydrophilic groups, molecular ...
23 Ph.D. students have completed their Ph.D. Currently, 2 students are pursuing Ph.D. in areas of genomics, proteomics, and drug design. Over 1056 participants have been trained in various aspects of bioinformatics through short-term training programs. SCFBio has organized several workshops and international conferences including InCoB 2006.
February 1, 2025 at 2:53 PM (CBS DETROIT) — A 5-year-old Michigan boy was killed Friday morning when a hyperbaric chamber he was inside of exploded, officials said.
In analogy to the rule of five, it has been proposed that ideal fragments should follow the 'rule of three' (molecular weight < 300, ClogP < 3, the number of hydrogen bond donors and acceptors each should be < 3 and the number of rotatable bonds should be < 3). [4]
Here is what we know about polio as a disease, its vaccines and the likely number of lives saved through inoculation.
Johnny Weir and Tara Lipinski American Airlines flight 5342 collided with a U.S. Army Black Hawk helicopter over the Potomac River in the Washington, D.C. area on Wednesday, Jan. 29