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Clonazepam, sold under the brand name Klonopin among others, is a benzodiazepine medication used to prevent and treat anxiety disorders, seizures, bipolar mania, agitation associated with psychosis, obsessive–compulsive disorder (OCD), and akathisia. [11] It is a long-acting [12] tranquilizer of the benzodiazepine class. [11]
Approximately 3 percent of people who are alcohol dependent experience psychosis during acute intoxication or withdrawal. Alcohol-related psychosis may manifest itself through a kindling mechanism. The mechanism of alcohol-related psychosis is due to distortions to neuronal membranes, gene expression, as well as thiamine deficiency. It is ...
The authors also warned of the similarities in pharmacology and mechanism of action of the newer nonbenzodiazepine Z drugs. [136] The elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals. Many doctors do not adjust benzodiazepine ...
In terms of the mechanism of action of benzodiazepines, their similarities are too great to separate them into individual categories such as anxiolytic or hypnotic. For example, a hypnotic administered in low doses produces anxiety-relieving effects, whereas a benzodiazepine marketed as an anti-anxiety drug at higher doses induces sleep. [175]
Benzodiazepines share a similar mechanism of action with various sedative compounds that act by enhancing the GABA A receptor. Cross tolerance means that one drug will alleviate the withdrawal effects of another. It also means that tolerance of one drug will result in tolerance of another similarly-acting drug.
In addition to treating anxiety and seizures, clonazepam also has off-label uses for restless leg syndrome, acute mania, insomnia and the neurological condition tardive dyskinesia, which causes ...
Additional packages of clonazepam, a prescription medication used to treat seizures and anxiety, mislabeled with the incorrect strength have been added to a voluntary recall, according to the U.S ...
Clobazam as with other benzodiazepine drugs can lead to physical dependence, addiction, and what is known as the benzodiazepine withdrawal syndrome. Withdrawal from clobazam or other benzodiazepines after regular use often leads to withdrawal symptoms which are similar to those seen during alcohol and barbiturate withdrawal. The higher the ...