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Neuromuscular blocking drugs are often classified into two broad classes: Pachycurares, which are bulky molecules with nondepolarizing activity; Leptocurares, which are thin and flexible molecules that tend to have depolarizing activity. [5] It is also common to classify them based on their chemical structure.
Depolarizing neuromuscular blockers: Depolarizing agents act as agonists for acetylcholine receptors. Succinylcholine is currently the only depolarizing neuromuscular blocking drug that has been placed in ongoing clinical use. Its pharmacological structure resembles two acetylcholine molecules combined through acetate methyl groups. [11]
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A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeutic groups: neuromuscular blockers and spasmolytics.
Rocuronium bromide is a competitive antagonist for the nicotinic acetylcholine receptors at the neuromuscular junction. Of the neuromuscular-blocking drugs it is considered to be a non-depolarizing neuromuscular junction blocker, because it acts by dampening the receptor action causing muscle relaxation, instead of continual depolarisation which is the mechanism of action of the depolarizing ...
Pancuronium, the first aminosteroid neuromuscular blocking agent to be introduced. Aminosteroids are a group of steroids with a similar structure based on an amino - substituted steroid nucleus. [ 1 ] [ 2 ] They are neuromuscular blocking agents , acting as competitive antagonists of the nicotinic acetylcholine receptor (nAChR), and block the ...
Atracurium is in the neuromuscular-blocker family of medications and is of the non-depolarizing type. [1] It works by blocking the action of acetylcholine on skeletal muscles. [1] Atracurium was approved for medical use in the United States in 1983. [1] It is on the World Health Organization's List of Essential Medicines. [3]
Tubocurarine has a time of onset of around 5 minutes which is relatively slow among neuromuscular-blocking drugs, and has a duration of action of 60 to 120 minutes. [ 19 ] [ 20 ] It also causes histamine release, [ 21 ] now a recognized hallmark of the tetrahydroisioquinolinium class of neuromuscular blocking agents.
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related to: neuromuscular blocking drugs names and pictures- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
