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Neuroinflammation is inflammation of the nervous tissue. It may be initiated in response to a variety of cues, including infection, traumatic brain injury, [1] toxic metabolites, or autoimmunity. [2] In the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in ...
Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. [1][2][3][4] Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques.
Radiology, neurology. Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. [1] There are two types of ARIA: ARIA-E and ARIA-H.
Learning about the dementia stages can help caregivers track and monitor stage-related symptoms to identify a loved one’s brain-health status. The seven stages of dementia include: Stage 1: No ...
"Shingles may contribute to dementia risk through neuroinflammation, ... which typically appears as a stripe around one side of the body or face, symptoms can include fever, chills, headache and ...
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [ 1 ] Amyloid beta is a short peptide that is an abnormal ...
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, [ 2 ] and is the cause of 60–70% of cases of dementia. [ 2 ][ 15 ] The most common early symptom is difficulty in remembering recent events. [ 1 ] As the disease advances, symptoms can include problems with language, disorientation ...
A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration. [2][3] Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple ...
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