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SM-102 is a synthetic amino lipid which is used in combination with other lipids to form lipid nanoparticles. [1] These are used for the delivery of mRNA-based vaccines, [2][3][4] and in particular SM-102 forms part of the drug delivery system for the Moderna COVID-19 vaccine. [5][6][7] Lipid nanoparticles are an extension of earlier RNA ...
mRNA in vitro transcription, innate and adaptive immunity activation. An mRNAvaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [ 1 ] The vaccine delivers molecules of antigen -encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that ...
A lipid nanoparticle is typically spherical with an average diameter between 10 and 1000 nanometers. Solid lipid nanoparticles possess a solid lipid core matrix that can solubilize lipophilic molecules. The lipid core is stabilized by surfactants (emulsifiers). The emulsifier used depends on administration routes and is more limited for ...
The Pfizer–BioNTech COVID-19 vaccine, sold under the brand name Comirnaty, [2][33] is an mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with the American company Pfizer to carry out clinical trials, logistics, and manufacturing. [45][46] It is authorized for use ...
The Moderna COVID‑19 vaccine, sold under the brand name Spikevax, is a COVID-19 vaccine developed by the American company Moderna, the United States National Institute of Allergy and Infectious Diseases (NIAID), and the Biomedical Advanced Research and Development Authority (BARDA). Depending on the jurisdiction, it is authorized for use in ...
A DNA vaccine is a type of vaccine that transfects a specific antigen -coding DNA sequence into the cells of an organism as a mechanism to induce an immune response. [1][2] DNA vaccines work by injecting genetically engineered plasmid containing the DNA sequence encoding the antigen (s) against which an immune response is sought, so the cells ...
In the U.S., where there is adequate supply, household contacts of infected people can seek the vaccine prophylactically. People in rural DRC also likely contract mpox from an unknown wild animal ...
Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research. Efforts to develop HIV vaccines targeting gp120, however, have been hampered by the chemical and structural properties of gp120, which make it difficult for antibodies to bind to it. gp120 can also easily be shed from the surface of the virus and captured by T cells ...