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Sarcoidosis is a disease of unknown cause characterized by non-necrotizing ("non-caseating") granulomas in multiple organs and body sites, [12] most commonly the lungs and lymph nodes within the chest cavity. Other common sites of involvement include the liver, spleen, skin, and eyes.
The cause of the condition is unknown. [6] [3] The disease is characterized by non-caseating granulomatous inflammation. [1]That is, the granulomas do not undergo the caseating ("cheese-like") necrosis typical of the granulomas of tuberculosis.
Sarcoidosis is characterized by the formation of non-necrotizing ("non-caseating") granulomas in various organs and tissues. [95] Giant cells, specifically Langhans giant cells, are often seen in sarcoidosis. [96] Schaumann bodies seen in sarcoidosis are calcium and protein inclusions inside of giant cells as part of a granuloma. [97]
Mycobacterium tuberculosis is the most common cause of both pulmonary tuberculosis and tuberculous lymphadenitis. [1] [6] Historically, transmission of Mycobacterium bovis from dairy consumption was another frequent cause of tuberculous lymphadenitis, but incidence has drastically decreased in developed countries since the advent of pasteurization and other efforts to prevent bovine ...
Caseous necrosis in the kidney. In caseous necrosis no histological architecture is preserved (unlike with coagulative necrosis). [5] [6] On microscopic examination with H&E staining, the area is acellular, characterised by amorphous, roughly granular eosinophilic debris of now dead cells, [6] also containing interspearsed haematoxyphilic remnants of cell nucleus contents. [5]
It is possible that, following an initial tuberculosis infection resulting in bacteremia, a foci of granulomatous inflammation may coalesce into a caseous tuberculoma. [20] Pulmonary tuberculomas may arise due to repeated cycles of necrosis and re-encapsulation of foci, or, alternatively, the shrinkage and fusion of encapsulated densities.
Although granulomatous mastitis is easily confused with cancer it is a completely benign (non-cancerous) condition. Treatment is radically different for idiopathic granulomatous mastitis and other granulomatous lesions of the breast. The precise diagnosis is therefore very important.
ICD-10 is the 10th revision of the International Classification of Diseases (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. [1]