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The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. [1] [2] The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method. The Fischer ...
[14] [15] Large scale reactions are usually carried out in a stirred tank reactor, a bubble column reactor or a tube reactor, followed by further processing depending on the target product. [16] In case of a stirred tank reactor, the lamp (generally shaped as an elongated cylinder) is provided with a cooling jacket and placed in the reaction ...
The Fischer oxazole synthesis is a type of dehydration reaction which can occur under mild conditions in a rearrangement of the groups that would not seem possible. The reaction occurs by dissolving the reactants in dry ether and passing through the solution dry, gaseous hydrogen chloride .
The photochlorination of hydrocarbon is unselective, although the reactivity of the C-H bonds is tertiary>secondary>primary. At 30 °C the relative reaction rates of primary, secondary and tertiary hydrogen atoms are in a relative ratio of approximately 1 to 3.25 to 4.43.
Fischer-Hepp rearrangement. This organic reaction was first described by the German chemist Otto Philipp Fischer (1852–1932) and Eduard Hepp (June 11, 1851 – June 18, 1917) [3] in 1886, and is of importance because para-NO secondary anilines cannot be prepared in a direct reaction.
The Wulff–Dötz reaction (also known as the Dötz reaction or the benzannulation reaction of the Fischer carbene complexes) is the chemical reaction of an aromatic or vinylic alkoxy pentacarbonyl chromium carbene complex with an alkyne and carbon monoxide to give a Cr(CO) 3-coordinated substituted phenol. [1] [2] [3] Several reviews have been ...
Factors governing organic reactions are essentially the same as that of any chemical reaction.Factors specific to organic reactions are those that determine the stability of reactants and products such as conjugation, hyperconjugation and aromaticity and the presence and stability of reactive intermediates such as free radicals, carbocations and carbanions.
Finkelstein reaction [25] Fischer indole synthesis; Fischer oxazole synthesis; Fischer peptide synthesis; Fischer phenylhydrazine and oxazone reaction; Fischer glycosidation; Fischer–Hepp rearrangement; Fischer–Speier esterification; Fischer Tropsch synthesis; Fleming–Tamao oxidation; Flood reaction; Folin–Ciocalteu reagent; Formox ...