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162,041 structures in the PDB have a structure factor file. 11,242 structures have an NMR restraint file. 5,774 structures in the PDB have a chemical shifts file. 13,388 structures in the PDB have a 3DEM map file deposited in EM Data Bank. Most structures are determined by X-ray diffraction, but about 7% of structures are determined by protein ...
Research Collaboratory for Structural Bioinformatics Protein Database (RCSB PDB) Protein Data Bank in Europe (PDBe) Protein Data Bank Japan (PDBj) Biological Magnetic Resonance Data Bank (BMRB) Electron Microscopy Data Bank (EMDB). The wwPDB was founded in 2003 by RCSB PDB (USA), PDBe (Europe) and PDBj (Japan). In 2006 BMRB (USA) joined the wwPDB.
The PDB file format was invented in 1972 [2] [3] as a human-readable file that would allow researchers to exchange the atomic coordinates in a given protein through a database system. Its fixed-column width format is limited to 80 or 140 [ 4 ] columns, which was based on the width of the computer punch cards that were previously used to ...
The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the PH domain.The PH domain functions mainly in the interaction of PDPK1 with phosphatidylinositol (3,4)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate which is important in localization and activation of some of membrane associated PDPK1's substrates including AKT.
Because the PDB releases data into the public domain, the data has been used in various other protein structure databases. Examples of protein structure databases include (in alphabetical order); Database of Macromolecular Movements describes the motions that occur in proteins and other macromolecules, particularly using movies Dynameomics
Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. [5] [6] Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. [7]
Amyloid-beta precursor protein is an ancient and highly conserved protein. [11] In humans, the gene APP is located on chromosome 21 and contains 18 exons spanning 290 kilobases.
15183 Ensembl ENSG00000171720 ENSMUSG00000024454 UniProt O15379 O88895 RefSeq (mRNA) NM_003883 NM_010411 RefSeq (protein) NP_003874 NP_001341968 NP_001341969 NP_001341970 NP_034541 Location (UCSC) Chr 5: 141.62 – 141.64 Mb Chr 18: 38.07 – 38.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice ...