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Macrophage polarization is a process by which macrophages adopt different functional programs in response to the signals from their microenvironment. This ability is connected to their multiple roles in the organism: they are powerful effector cells of the innate immune system, but also important in removal of cellular debris, embryonic development and tissue repair.
The intermediate monocyte expresses high levels of CD14 and low levels of CD16 (CD14 ++ CD16 + monocytes). While in humans the level of CD14 expression can be used to differentiate non-classical and intermediate monocytes, the slan (6-Sulfo LacNAc) cell surface marker was shown to give an unequivocal separation of the two cell types. [10] [11]
Illustrated schematic of monocytes, monocyte-derived macrophages, and liver-resident Kupffer cells. Monocytes and macrophages are mononuclear phagocytes. Monocytes circulate in the blood and are capable of differentiating into macrophages or dendritic cells, and macrophages are terminally differentiated tissue-resident cells.
Erythropoietin, which stimulates red blood cell production, increases throughout pregnancy and reaches approximately 150 percent of their pregnancy levels at term. [24] The slight drop in hematocrit or hemoglobin is most pronounced at the end of the second trimester and slowly improves when reaching term. [24]
Macrophages accumulate in visceral fat and other tissues with age, leading to chronic inflammation. [55] The inflammatory transcription factor NF-κB and CD38 are mutually activating. [54] Secretions from senescent cells induce high levels of expression of CD38 on macrophages, which becomes the major cause of NAD+ depletion with age. [56]
General macrophage targets [11] [8] Alveolar macrophage: Monocyte: Macrophage: Pulmonary macrophage; Dust cell; 20-21 Carbon debris from lungs; General macrophage targets [8] Dendritic cell: Monocyte: Dendritic cell: DC; Cellula dendritiformis; 10-15 Process antigen material and present to the T cell; Messengers between innate and adaptive ...
It also is a marker of cells from the monocyte/macrophage lineage. [8] CD163 functions as innate immune sensor for gram-positive and gram-negative bacteria. [9] [10] The receptor was discovered in 1987. [11]
The activation of T H 1 and M1 macrophage is a positive feedback loop, with IFN-γ from T H 1 cells upregulating CD40 expression on macrophages; the interaction between CD40 on the macrophages and CD40L on T cells activate macrophages to secrete IL-12; and IL-12 promotes more IFN-γ secretion from T H 1 cells.
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