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Microangiopathy (also known as microvascular disease, small vessel disease (SVD) or microvascular dysfunction) is a disease of the microvessels, small blood vessels in the microcirculation. [1] It can be contrasted to macroangiopathies such as atherosclerosis , where large and medium-sized arteries (e.g., aorta , carotid and coronary arteries ...
There are two types of angiopathy: macroangiopathy and microangiopathy. [2] In macroangiopathy, atherosclerosis and a resultant blood clot forms on the large blood vessels, sticks to the vessel walls, and blocks the flow of blood. Macroangiopathy in the heart is coronary artery disease; in the brain, it is cerebrovascular disease.
Damage to small blood arteries is the cause of what called microangiopathy, which may lead to any of these: Diabetic retinopathy , caused by alterations in retinal microcirculation, leading to the growth of friable and poor-quality new blood vessels in the retina or capillary closure which causes ischemia or extravasation of intravascular ...
Thrombotic microangiopathy (TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury. [1] It may be seen in association with thrombocytopenia , anemia , purpura and kidney failure .
"Onion-skin" renal arteriole. This is a type of arteriolosclerosis involving a narrowed lumen. [4] The term "onion-skin" is sometimes used to describe this form of blood vessel [14] with thickened concentric smooth muscle cell layer and thickened, duplicated basement membrane.
Kidney biopsy showing thrombotic microangiopathy, a histomorphologic finding seen in malignant hypertension. The pathophysiology of hypertensive emergency is not well understood. Failure of normal autoregulation and an abrupt rise in systemic vascular resistance are typical initial components of the disease process. [6]
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Some aspects can be traced as far back as F. L. Hitchcock in 1928, [1] but it was L. R. Tucker who developed for third-order tensors the general Tucker decomposition in the 1960s, [2] [3] [4] further advocated by L. De Lathauwer et al. [5] in their Multilinear SVD work that employs the power method, or advocated by Vasilescu and Terzopoulos ...