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Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
Variants in this gene can cause hereditary nonpolyposis colon cancer (Lynch syndrome). It is a human homolog of the E. coli DNA mismatch repair gene, mutL, which mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal.
From Wikipedia, the free encyclopedia. Redirect page. Redirect to: Hereditary nonpolyposis colorectal cancer
The William Lynch speech, also known as the Willie Lynch letter, is an address purportedly delivered by a William Lynch (or Willie Lynch) to an audience on the bank of the James River in Virginia in 1712 regarding control of slaves within the colony. [1] In recent years, it has been widely exposed as a hoax. [2] [3]
An enslaver by the name of Willie Lynch was said to have allegedly written a pamphlet that widely circulated instructing enslavers on how to use brutality to control enslaved people. "The Willie ...
[9] [10] His article was one of the first to make the case that cancer was heritable in humans, and the medical pedigree of family G (which was later determined to suffer from hereditary nonpolyposis colorectal cancer or Lynch Syndrome) is one of the longest and most detailed cancer genealogies in the world. [11]
OPINION: Perhaps the first viral digital hoax, we celebrate white Juneteenth with a long-overdue response to the (fake) Willie Lynch Letter explaining the invention of whiteness.
His best-known example, hereditary nonpolyposis colorectal cancer, is the most common form of hereditary colorectal cancer and is generally known as Lynch syndrome. He demonstrated the Mendelian inheritance pattern for certain breast and ovarian cancers, which laid the groundwork for the identification of specific genes responsible for these ...