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These examples demonstrate that to properly understand a value for TIBC, one also must know the serum iron, the percent transferrin saturation, and the individual clinical situation. In modern laboratory testings, serum ferritin levels are generally accepted as reliable single indicators of the presence of iron deficiency. [citation needed]
In the setting of anemia, low serum ferritin is the most specific lab finding for iron-deficiency anemia. [34] However it is less sensitive, since its levels are increased in the blood by infection or any type of chronic inflammation, [ 35 ] and these conditions may convert what would otherwise be a low level of ferritin from lack of iron, into ...
The platelet count may be slightly above the high limit of normal in iron-deficiency anemia (termed a mild thrombocytosis), but severe cases can present with thrombocytopenia (low platelet count). [58] Iron-deficiency anemia is confirmed by tests that include serum ferritin, serum iron level, serum transferrin, and total iron binding capacity. [59]
Total iron-binding capacity increases when iron deficiency exists. [4] Serum ferritin levels reflect the iron stores available in the body. [4] The normal range is 20 to 200 ng/mL for men and 15 to 150 ng/mL for women. [8] Low levels (< 12 ng/mL) are specific for iron deficiency. [4]
Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells.
Transferrin saturation (TS), measured as a percentage, is a medical laboratory value. It is the value of serum iron divided by the total iron-binding capacity [1] of the available transferrin, the main protein that binds iron in the blood, this value tells a clinician how much serum iron is bound. For instance, a value of 15% means that 15% of ...
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