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The primary sites of end-target organ damage following an increase in arterial stiffness are the heart, the brain (stroke, white matter hyperintensities (WMHs)), the placenta, and the kidneys (age-related loss of kidney function). [21] Firstly, stiffened arteries compromise the Windkessel effect of the arteries. [22]
Plaque build-up often doesn’t cause symptoms, but it can block blood flow to vital organs like your heart. Coronary artery disease occurs when atherosclerosis affects the arteries supplying ...
Coronary artery disease (CAD) is the most common cause of coronary ischemia. [7] Coronary ischemia and coronary artery disease are contributors to the development of heart failure over time. [ 10 ] Diagnosis of coronary ischemia is achieved by an attaining a medical history and physical examination in addition to other tests such as ...
Each year in the United States, according to the Centers for Disease Control and Prevention (CDC), about 735,000 people have a heart attack and 610,000 people die of coronary heart disease (CHD).
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries.This is a chronic inflammatory disease involving many different cell types and is driven by elevated levels of cholesterol in the blood. [9]
A condition called peripheral artery disease (PAD), for example, occurs when the arteries that carry blood from the heart to the legs get clogged; it’s associated with an increased risk of heart ...
[1] [2] An occlusion of arteries disrupts oxygen and blood supply to tissues, leading to ischemia. [1] Depending on the extent of ischemia, symptoms of arterial occlusion range from simple soreness and pain that can be relieved with rest, [3] to a lack of sensation or paralysis that could require amputation. [3]
Coronary artery ectasia is characterized by an increased wall stress of the vessel, thinning of the arterial wall which causes progressive dilation and remodelling of the vessel. [2] The permanent dilation of the artery is thought to be mainly caused by inflammation, triggered by disease, chemicals, or physical stress of the vessel. [3]