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Lectins are similar to antibodies in their ability to agglutinate red blood cells. [33] Many legume seeds have been proven to contain high lectin activity, termed hemagglutination. [34] Soybean is the most important grain legume crop in this category. Its seeds contain high activity of soybean lectins (soybean agglutinin or SBA).
In medicine these proteins are useful and are used as a mitogen to trigger T-lymphocyte cell division and to activate latent HIV-1 from human peripheral lymphocytes.In neuroscience, anterograde tracing is a research method that uses the protein product phytohaemagglutinin PHA-L as a molecular tracer that can be taken up by the cell and transported across the synapse into the next cell thereby ...
Steven R. Gundry (born July 11, 1950) is an American physician, low-carbohydrate diet author and former cardiothoracic surgeon. [1] [2] Gundry is the author of The Plant Paradox: The Hidden Dangers in "Healthy" Foods That Cause Disease and Weight Gain, which promotes the controversial and pseudoscientific lectin-free diet. [3]
The Lectin-free diet (also known as the Plant Paradox diet) is a fad diet promoted with the false claim that avoiding all foods that contain high amounts of lectins will prevent and cure disease. [1] There is no clinical evidence the lectin-free diet is effective to treat any disease and its claims have been criticized as pseudoscientific. [2 ...
Soybean agglutinins (SBA) also known as soy bean lectins (SBL) are lectins found in soybeans. It is a family of similar legume lectins. As a lectin, it is an antinutrient that chelates minerals. In human foodstuffs, less than half of this lectin is deactivated even with extensive cooking (boiling for 20 minutes). [1]
Wheat germ agglutinin (WGA) is a lectin that protects wheat from insects, yeast and bacteria. An agglutinin protein, it binds to N-acetyl-D-glucosamine and sialic acid . [ 1 ] WGA has also been shown to interact with sialic acid residues on oligosaccharides. [ 2 ]
Some kinds of raw beans contain a harmful, flavourless toxin: the lectin phytohaemagglutinin, which must be destroyed by cooking. Red kidney beans are particularly toxic, but other types also pose risks of food poisoning. Even small quantities (4 or 5 raw beans) may cause severe stomachache, vomiting, and diarrhea.
The legume lectins are also interesting from the point of view of protein structure. Despite the conserved structure of the legume lectin subunit, they can adopt a wide range of quaternary structures. [4] [5] The reason behind this remarkable variability is probably to be found in the interaction with multivalent ligands. [6]
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