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The aPTT-based APC resistance test involves a modified aPTT test performed in the presence and absence of activated protein C (APC). [1] [5] The ratio of these aPTT values is calculated and is called the APC sensitivity ratio (APCsr) or simply APC ratio (APCr). [1] [5] This ratio is inversely related to the degree of APC resistance. [7]
The mortality of arterial thromboembolism in cats is very high. Fifty to 60% of affected animals are euthanized without attempted treatment, and only one-quarter to one-third of animals survive such an event. In about half of the recovered cats, thromboembolism recurs despite anticoagulation prophylaxis.
The partial thromboplastin time (PTT), also known as the activated partial thromboplastin time (aPTT or APTT), is a blood test that characterizes coagulation of the blood. A historical name for this measure is the Kaolin-cephalin clotting time ( KCCT ), [ 1 ] reflecting kaolin and cephalin as materials historically used in the test.
5340 18815 Ensembl ENSG00000122194 ENSMUSG00000059481 UniProt P00747 P20918 RefSeq (mRNA) NM_001168338 NM_000301 NM_008877 RefSeq (protein) NP_000292 NP_001161810 NP_032903 Location (UCSC) Chr 6: 160.7 – 160.75 Mb Chr 17: 12.6 – 12.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Plasminogen activator inhibitor-1 not only functions as an inhibitor, but other roles of PAI-1 ...
Cats may be poisoned by many chemicals usually considered safe by their human guardians, [citation needed] because their livers are less effective at some forms of detoxification. [31] [32] Some of the most common causes of poisoning in cats are antifreeze and rodent baits. [33] Cats may be particularly sensitive to environmental pollutants. [34]
Lysine is commonly used as a treatment; however, in a 2015 systematic review, the authors investigated all clinical trials with cats as well as in vitro studies and concluded that lysine supplementation is likely not effective for the treatment or prevention of feline herpesvirus 1 infection. [15]
During these episodes, affected cats can be extremely difficult to distract from their behaviour, and often appear to be absent-minded or in a trance-like state. [4] [5] Overall, the prognosis for the syndrome is good, so long as the syndrome does not result in excessive self-aggression and self-mutilation that may lead to infection. [1]
Treatment may include activated charcoal if the person seeks medical help soon after the overdose. [1] Attempting to force the person to vomit is not recommended. [6] If there is a potential for toxicity, the antidote acetylcysteine is recommended. [1] The medication is generally given for at least 24 hours. [6]
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